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Director, Translational Medicine Expert (Neurodegeneration)Novartis · Cambridge (USA)
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Director, Translational Medicine Expert (Neurodegeneration)

🗓️ Posted 2026-09-25 Cambridge (USA) Hybrid Healthcare Medical
💰 Salary US$20,708–US$38,458/mo (US$248,500–US$461,500/yr) 📊 Market US$16,667–US$25,000/mo

About the Company

Job Description Summary LI-Hybrid Internal Title: Director Location: Cambridge, MA, USA The Director, Translational Medicine Expert (Neurodegeneration) will lead the end to end translational strategy for neurodegenerative programs, bridging preclinical research to early clinical development (Phase 1-2). This role is accountable for biomarker strategy, clinical endpoint selection, and early phase trial design, enabling efficient, data driven decision-making through key development milestones (e.g., Transition Decision Points) and ensuring competitive differentiation of neuromuscular assets. In addition, he/she oversees the planning, execution, and interpretation of clinical trials research, data collection activities and clinical operations. Establishes and approves scientific methods for design and implementation of clinical protocols, data collection systems and final reports. Support new and ongoing clinical research and clinical trials and ensure efficient and timely processing of confidentiality agreements and clinical agreements Job Description

Responsibilities

  • ● Translational Strategy & Program Leadership
  • ● Define and execute integrated translational strategies across neurodegeneration programs
  • ● Lead translational components from preclinical Phase 1/2 clinical studies
  • ● Drive program progression through key decision gates (e.g., IND, TDP, IDPA)
  • ● Ensure strong mechanistic linkage between target biology, biomarkers, and clinical endpoints
  • ● Biomarker & Endpoint Leadership
  • ● Collaborate with Biomarker Development colleagues toward development and validation of:
  • ● Molecular biomarkers (tissue, blood, CSF where applicable)
  • ● Functional endpoints (strength, mobility, disease-specific measures)
  • ● Patient-reported outcomes (PROs)
  • ● Establishing quantitative biomarkers to support:
  • ● Target engagement
  • ● Disease modification
  • ● Dose selection and PoC decisions
  • ● Integrate biomarker strategy into clinical protocols and operational plans
  • ● Drive early biomarker de risking , a key priority in neuromuscular programs
  • ● Early Clinical Development (Phase 1/2)
  • ● Co lead design and execution of early clinical studies
  • ● Dose escalation strategy
  • ● Exposure-response framework

Requirements

  • ● MD, neurologists, clinical training in neurodegenerative diseases
  • ● Experience in translational medicine, early clinical development, or experimental therapeutics.
  • ● Ability to shape development strategies, execute early clinical studies, and influence regulatory/packages supporting differentiation.
  • ● Experience working in pharmaceutical/biotech company strongly preferred.
  • ● PhD, PharmD, or equivalent in:
  • ● o Neurology / Neuroscience
  • ● o Neurodegenerative diseases
  • ● The salary for this position is expected to range between: 248,500-- 461,500/year
  • ● The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.
  • ● US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
  • ● To learn more about the culture, rewards and benefits we offer our people click here .
  • ● EEO Statement:
  • ● The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.
  • ● Accessibility and reasonable accommodations
  • ● The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
  • ● Salary Range 248,500.00 - 461,500.00