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Scientist, High Throughput Antibody ProductionAstraZeneca · US - Cambridge Kendall SQ - MA
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AstraZeneca

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Scientist, High Throughput Antibody Production

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🗓️ Posted 2026-09-25 US - Cambridge Kendall SQ - MA Full-time Hybrid Science Technology
💰 Salary 7,688 GBP–11,532 GBP/mo (92,252 GBP–138,378 GBP/yr) 📊 Market 6,000 GBP–10,000 GBP/mo

About the Company

Biologics Engineering (BE) is a large, global organization with teams in Cambridge, UK; Gaithersburg, MD; and Cambridge, MA. We discover and optimize next-generation biologics for therapeutic areas including oncology, respiratory and immunology, and cardiovascular, renal and metabolic diseases. Our Cambridge, MA team is building an innovation center and lighthouse laboratory that combines scientific expertise, high-throughput automation, robotics, and digital orchestration to expand what is possible in biologics discovery. Through close collaboration across disciplines and geographies, we deliver high-quality therapeutic molecules that advance the R&D pipeline and address unmet patient needs. Role Summary: We are seeking a highly organized, detail-oriented Scientist to join our High-Throughput Production (HTP) team in Cambridge, MA. The successful candidate will use an advanced, integrated robotics laboratory to routinely produce, purify, and quality-control hundreds of antibodies and antibody-like therapeutic molecules each week in support of R&D pipeline programs. Working within validated, end-to-end automated workflows designed to enable near-lights-out production, this role is accountable for reliable execution, complete documentation, instrument and material readiness, and timely delivery of high-quality samples and data. Success requires hands-on high-throughput production experience, fundamental knowledge of protein expression and purification, disciplined

Requirements

  • ● Master's degree in biochemistry, biotechnology, cell biology, molecular biology, chemical engineering, or a related discipline, with 1+ years of relevant experience in high-throughput protein or antibody expression, purification, or analytical characterization.
  • ● Bachelor's degree in a related scientific or engineering discipline, with 5+ years of relevant experience in high-throughput protein or antibody expression, purification, or analytical characterization.
  • ● Required Skills
  • ● Demonstrated hands-on experience with high-throughput production of antibodies or recombinant proteins, including routine execution of standardized workflows at microgram-to-milligram scale.
  • ● Hands-on experience operating automated liquid handlers; experience with Hamilton or Lynx platforms is preferred, and familiarity with integrated robotics or scheduling/orchestration software such as Cellario is strongly valued.
  • ● Fundamental understanding of recombinant protein expression and purification, including mammalian cell culture, aseptic technique, transient transfection, affinity capture, buffer exchange, concentration, and factors that affect yield and product quality.
  • ● Experience with sample tracking and laboratory logistics/LIMS software; comfort with barcode-driven workflows.
  • ● Strong organizational skills and the ability to prepare production runs, manage multiple samples and consumables, maintain accurate records, and consistently meet time-sensitive weekly deliverables.
  • ● Exceptional attention to detail, documentation rigor, and demonstrated ability to follow detailed SOPs, work instructions, process controls, and QC acceptance criteria without compromising quality or traceability.
  • ● Team-oriented, dependable, and collaborative, with clear written and verbal communication skills and a willingness to coordinate closely, share workload, and support colleagues across production, QC, automation, and pipeline-facing teams.
  • ● Desired Skills
  • ● Working knowledge of protein purification technologies and common analytical methods (e.g., SEC-UPLC, LC-MS, SDS-PAGE, CE).
  • ● Familiarity with lab automation scheduling software; Cellario preferred.
  • ● Basic scripting for data handling (e.g., Python, Jupyter) is a plus, not required.
  • ● Why AstraZeneca
  • ● At AstraZeneca, we push the boundaries of science to deliver life-changing medicines. You will join a globally connected team at the intersection of biologics science, automation, and operational excellence, using an innovative robotics laboratory to deliver therapeutic molecules at the pace and quality required by our R&D pipeline. This is an opportunity to contribute directly to a high-performing production team whose reliable execution enables discovery programs around the world.
  • ● Diversity and Inclusion at AstraZe neca
  • ● We believe that diversity drives innovation. AstraZeneca is committed to building an inclusive culture that celebrates diverse perspectives and fosters belonging. We welcome all qualified applicants and ensure compliance with applicable laws regarding inclusivity and employment eligibility. Individuals with disabilities can request reasonable accommodations throughout the recruitment process.
  • ● Are you interested in working at AZ, apply today
  • ● Apply now and help shape the future of therapeutic protein production.