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AstraZeneca

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Translational Science Lead

🗓️ Posted 2026-08-14 UK - Cambridge Full-time Hybrid Science Technology

Company shared salary

NA

Market rate

5,417 GBP–8,333 GBP/mo (65,004 GBP–99,996 GBP/yr)

Based on similar roles (title + domain + location).

About the Company

Are you ready to convert human biology into decisive clinical evidence that transforms how we treat respiratory disease Can you see yourself shaping biomarker strategies that define who benefits most from our medicines Based in Cambridge and reporting to the Senior Group Director, Translational Science, you will lead translational strategy from target selection through early clinical development for respiratory programs. You will connect mechanistic insight to patient impact, delivering clear proof-of-mechanism, target engagement, and precision medicine strategies that guide development decisions and position assets for differentiation and lifecycle opportunities. Working at the intersection of discovery, clinical development and data science, you will design integrated plans, build external collaborations and patient cohorts, and champion the scientific narrative through governance. Your leadership will ensure biomarker assays are fit-for-purpose in the clinic, translational readouts are robust, and the right patients are identified sooner-accelerating the path from mechanism to medicine. Accountabilities: Translational Strategy Leadership: Own and integrate end-to-end translational strategies for respiratory projects and clinical studies, spanning human target validation, target engagement and precision medicine, to drive program decision-making. Human Target Validation: Define human validation plans at target selection, leveraging public and proprietary biobanks t

Requirements

  • ● PhD with a strong experimental drive and background in Respiratory field
  • ● Post-doc experience or otherwise relevant scientific research experience
  • ● + years of experience in a Biomedical or Pharmaceutical role
  • ● Strong publication record
  • ● Proven ability to deliver translational readouts and human target validation and their application to drug discovery.
  • ● Understanding of the Respiratory therapy area including but not limited to COPD, Asthma, NCFBE and IPF, and disease biology, including related molecular pathways and mechanisms.
  • ● Broad understanding of relevant technologies and methodologies along with excellent scientific skills and ability to design experiments to address key scientific questions.
  • ● Excellent skills in hypothesis forming and testing and able to draw conclusions and suggest next steps based on the experimental data.
  • ● Understanding of pharmacology, translational medicine and clinical sciences as well as clinical development with pre-eminence in at least one of these areas.
  • ● Demonstrated leadership skills, ability to be a self-starter.
  • ● Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects.
  • ● Excellent written, oral, presentation and interpersonal skills.
  • ● prior experience in a Scientific role within the Biomedical or Pharmaceutical Industry
  • ● Why AstraZeneca:
  • ● Here, you are empowered to follow the science with curiosity and courage, digging deep into the biology of complex disease while harnessing digital, data science and AI to uncover new insights. Unexpected teams often find themselves in the same room, unleashing bold thinking that advances the next generation of therapeutics and improves the odds of clinical success. You will be trusted to explore, supported with the tools and pipeline of a leading R&D organization, and surrounded by collaborators across academia, biotechs and industry-all united by a shared purpose to move faster for patients. We value kindness alongside ambition, balancing big goals with the openness and resilience needed to navigate uncertainty and create meaningful impact.
  • ● What is next
  • ● We look forward to receiving your application not later than 28th August 2026
  • ● If you are ready to turn mechanism into medicine and define how translational science accelerates life-changing respiratory therapies, bring your expertise to Cambridge and make your impact today
  • ● Date Posted 14-Aug-2026
  • ● Closing Date 28-Aug-2026