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Executive Director Clinical Operations, Program ManagementAstraZeneca · UK - Cambridge
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AstraZeneca

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Executive Director Clinical Operations, Program Management

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🗓️ Posted 2026-09-19 UK - Cambridge Full-time Hybrid Healthcare Medical
💰 Salary Not shared 📊 Market 10,000 GBP–15,000 GBP/mo

About the Company

We're transforming the future of healthcare by unlocking the power of what science can do for people, society and the planet. For more information, visit www.astrazeneca.com. Community Guidelines: bit.ly/2MgAcio Pharmaceutical Manufacturing Specialties: Pharmaceutical, Biopharmaceutical, Innovation, Research and development, Global business

About the Role

Are you ready to lead a global cell therapy clinical operations franchise that accelerates life-changing treatments for patients across oncology, rare disease, and autoimmune conditions As Executive Director Clinical Operations, Program Management (ED, CTPM), you will own strategic leadership and end-to-end delivery for a pivotal autologous cell therapy portfolio spanning phase 1 through registrational studies. Your decisions will determine how quickly and reliably our programs reach patients, and how we scale a portfolio with rigor, pace, and quality. Reporting to the Head of Cell Therapy Clinical Operations, you will shape and standardize ways of working across multiple programs and geographies, partnering with senior operational and clinical leaders to ensure predictable execution to time, cost, and quality. You will build a high-performing team of Senior Director-level program managers, strengthen capabilities, and set a clear vision, metrics, and governance that elevate performance across the franchise.

Responsibilities

  • ● Define and steward short- and long-term clinical operations strategy across all programs, ensuring clarity of direction and a robust path to delivery.
  • ● Develop a cohesive franchise-wide approach covering therapeutic clinical operations, country footprint and site strategy, and consistent, deliverable operational clinical development plans.
  • ● Drive resolution and consistency for franchise-level clinical operations issues impacting multiple global product teams.
  • ● Provide strategic oversight and global leadership for all in-scope cell therapy studies to deliver to agreed time and cost, with unwavering focus on quality and regulatory compliance.
  • ● Serve as clinical operations franchise leader at enterprise-level cell therapy governance; act as a core member of the Protocol Review Committee for CTCO leadership sign-off; ensure studies are operationally robust ahead of Development Review Committee and ESPC/LSPC.
  • ● Establish and communicate the franchise delivery vision, strategy, prioritization, portfolio insights, and key performance metrics that drive accountability and continuous improvement.
  • ● Deliver a rigorous slot forecasting strategy and make data-driven prioritization decisions for the franchise in partnership with the CTTO global Executive Director for planning.
  • ● Ensure franchise-wide excellence in submission preparation and inspection readiness, embedding standards and proactive risk management.
  • ● Build strong, capable, and passionate teams of Clinical Operations Program Leaders; attract, develop, and retain Senior Director-level talent; foster excellence in cell therapy trial execution.
  • ● Act as a core member of the Cell Therapy Clinical Operations Leadership Team, shaping department strategy, functional build, and forward planning.
  • ● Engage with industry leaders to bring external innovation into CTCO; benchmark, pilot, and scale practices that improve speed, quality, and patient impact.
  • ● Sponsor large-scale transformational initiatives that drive significant change and improvement across the franchise.