Senior Scientist Digital Biopharmaceutics

About the Company

About the Role

Responsibilities

• ● and a practical understanding of modelling and simulation. You will translate complex evidence into clear recommendations, champion robust predictive approaches and help embed reusable digital methodologies that improve decisions across the drug-development lifecycle.
• ● Strategic Project Leadership
• ● Define the biopharmaceutics strategy for assigned projects, with a strong emphasis on digital and model-informed approaches to guide formulation, bridging, and regulatory strategies.
• ● Champion the use of AstraZeneca's biopharmaceutics toolbox, particularly digital capabilities, to enable projects to save time, cost, and resources.
• ● Contribute to project plans by defining biopharmaceutics deliverables, milestones, and resource needs, working closely with project managers and unit leads to ensure efficient FTE allocation.
• ● Support the continuous improvement of unit ways of working, embedding new digital methodologies into standard practice.
• ● Digital Biopharmaceutics, Modelling & Simulation
• ● Apply and advance physiologically based biopharmaceutics modelling (PBBM), PBPK, and other in silico techniques to predict drug behaviour, optimise dosage regimens, and inform formulation and regulatory strategies.
• ● Build mechanistic understanding of in-vivo dissolution, absorption, or injection/aerosol performance to guide the selection of in-vitro characterisation tools and interpret drug product performance data.
• ● Work proactively to eliminate or minimise in-vivo studies as appropriate through robust, model-based justifications.
• ● Stay at the forefront of emerging digital methods, including machine learning, AI-driven predictive tools, and next-generation simulation platforms, and use project insights to guide science & technology (S&T) investment towards high-impact capability gaps.
• ● Communication & Stakeholder Engagement
• ● Engage effectively with project teams, unit leads, internal stakeholders, and external partners, presenting findings and championing the digital biopharmaceutics strategy.
• ● Clearly communicate and document risks, strategies, mitigations, and recommendations.
• ● Documentation, Reporting & Regulatory Contribution
• ● Ensure contemporaneous documentation of strategies, modelling work, and experimental results in electronic lab notebooks to capture project thinking and decision-making.
• ● Deliver internal and regulatory document authoring to agreed quality and timelines.
• ● Stay abreast of evolving regulatory expectations around model-informed drug development and biopharmaceutics, ensuring compliance with global guidelines and standards.

Requirements

• ● PhD (or MSc with substantial industry experience) in Pharmaceutical Sciences, Biopharmaceutics, Chemical Engineering, Pharmacokinetics, or a related subject area.
• ● Proficiency in scripting or programming (e.g., Python, R) for data analysis and model automation.
• ● Demonstrable expertise in biopharmaceutics modelling and simulation (e.g., GastroPlus, Simcyp, PK-Sim, or equivalent).
• ● Strong understanding of drug product performance, dissolution science, and in-vivo predictive dissolution testing (IVIVC/IVIVR).
• ● Excellent cross-functional collaboration and communication skills, with the ability to influence project strategy.
• ● Track record of peer-reviewed publications or conference contributions in digital biopharmaceutics.
• ● When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
• ● Are you ready to bring new ideas and fresh thinking to the table Great We welcome your application no later than 14 October 2026
• ● Date Posted 02-okt.-2026
• ● Closing Date 13-okt.-2026