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(Associate Director) Principal Clinical Pharmacologist, Cell Therapy DiscoveryAstraZeneca · Shanghai - Guilin Road
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AstraZeneca

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(Associate Director) Principal Clinical Pharmacologist, Cell Therapy Discovery

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🗓️ Posted 2026-09-29 Shanghai - Guilin Road Full-time Hybrid Healthcare Medical
💰 Salary Not shared 📊 Market 45,000 GBP–65,000 GBP/mo

About the Company

SUMMARY OF THE ROLE The Bioanalysis and Translational Medicine department centers on data driven bioanalysis and translational research, leveraging molecular/protein assays, cellular function and phenotyping, and biomarker with PK/PD platforms to support cell therapy programs including CAR T and mRNA LNP/lentiviral in vivo CAR. The Cell Therapy Clinical Pharmacologist leads the development and execution of pharmacology strategies for novel cell therapy, independently representing the department across clinical study and project teams. By applying quantitative principles to cellular kinetics and pharmacodynamics, the individual bridges early research and clinical application to optimize dosing and minimize unique toxicities like CRS. This role requires rigorous cross-functional collaboration to design, interpret, and report key studies-including first-in-human and drug interaction trials-ensuring the efficient advancement of drug candidates through regulatory approval. ROLE & RESPONSIBILITIES Lead the design, execution, and reporting of Clinical Pharmacology (CP) studies for IIT/Phase I clinical trials , including First-in-Human dose selection and Go/No-Go decision-making. Develop and align short-to-medium-term CP plans for assets across all development stages, ensuring integration with broader program goals. Author and finalize core clinical documents - including study protocols, Investigator ' s Brochures (IB), a

Requirements

  • ● Advanced degree (MD, MD/PhD, PhD or PharmD) in clinical pharmacology, pharmaceutical sciences or related fields such as pharmacokinetics, pharmacology or drug metabolism
  • ● Minimum of 5 years of experience working as a clinical pharmacologist in pharmaceutical industry, research institutions and/or regulatory agencies, with a strong track record in designing, interpreting, and reporting clinical pharmacology studies Skills & Capabilities
  • ● Ability to perform complex exposure-response and population-based kinetic modeling.
  • ● Expertise in analyzing large, multi-dimensional datasets including flow cytometry, cytokines, and molecular biomarkers.
  • ● Utilization of AI for the analysis and predictive models .
  • ● Strong ability to author high-quality clinical study reports (CSRs) and regulatory submissions.
  • ● Capability to lead multidisciplinary study teams and manage multiple clinical programs simultaneously. Desirable :
  • ● Deep expertise in pharmacokinetic/pharmacodynamics, drug metabolism, drug-drug interactions, and population PKPD and PBPK modelling, with hands-on experience using tools such as NONMEM, R, WinNonlin , and SimCyp
  • ● Broad familiarity with the drug development process, particularly for cell therapy , is highly desirable
  • ● Strong interpersonal, organizational, and communication skills; able to work independently and effectively within a collaborative matrix team environment
  • ● Ability to make sound judgements , adapt to changing business needs, and manage multiple priorities in complex settings
  • ● Excellent English communication skills, including cross-cultural collaboration and compelling scientific and program presentations
  • ● Date Posted 29-9月-2026
  • ● Closing Date
  • ● AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.